所属学科名称：中药药理

导师简介: 王遥

 

个人简介：

聚焦免疫应答不足或免疫应答过度所导致的炎症性肠病、糖尿病肾病、呼吸道感染及肿瘤等疾病，开展系统的疾病发病机制和中医药干预研究。在Nat Cell Biol、J Med Virol、EMBO J、Natl Sci Rev、Nat Commun、Acta Pharm Sin B等期刊发表研究性论文十余篇（均为中科院一区或TOP期刊），成果受到包括美国科学院院士在内的国内外专家的广泛关注。获授权国家发明专利9项，主持承担科技部科技创新2030重大课题、国自然面上、北京市科技新星、中华中医药学会青年人才托举工程、北京市面上、广东省面上、北京市科技新星交叉合作等科研项目十余项。任永利官网北京中医药研究院副经理、校青委会副秘书长，兼任中华中医药学会中药分析分会、感染病分会、免疫学分会、中国药品监督管理研究会中药监管专委会等委员职务。

主要研究方向：

1. 针对中药生物碱类、黄酮类、内酯类等开展系统的免疫药理研究，阐明具有相似化学结构的活性成分在防病、治病中的共性免疫学机制，“用现代科学解读中医药学原理”。

2. 探究炎症性肠病、糖尿病肾病、呼吸道感染和肿瘤等免疫相关疾病的发病机制，利用最新的生化分子、细胞生物学、遗传学和生物信息学研究手段，揭示上述疾病的发病机理，阐释中医药疾病防治的现代科学内涵。

科研成果：

1. Yao Wang*, Shaochun Yuan*, Xin Jia*, Yong Ge, Tao Ling, Meng Nie, Xihong Lan, Shangwu Chen, Anlong Xu^#. Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS. Nature Cell Biology. 21(11): 1346~1356. (2019) 中科院一区 IF：28.693

2. Cuiqin Cheng^#, Yao Wang^#*，Han Wang^#, Meiqi Zhang，Qiqi Li , Xin Jia*, Anlong Xu*. The phytochemical Alkaloids orchestrate immunometabolism against viral infections. National Science Review，(2024) 拟接收，中科院一区 IF：18.599

3. Jing Huang^#, Yao Wang^#*, Xin Jia, Changfeng Zhao, Meiqi Zhang, Mi Bao, Pan Fu, Cuiqin Cheng, Ruona Shi, Xiaofei Zhang, Jun Cui, Gang Wan, Anlong Xu. The human disease-associated gene ZNFX1 controls inflammation through inhibition of the NLRP3 inflammasome. The EMBO Journal, (2024)中科院一区 IF：9.4

4. Xue Liang^#, Kunpeng Liu^#, Xin Jia^#, Cuiqin Cheng, Meiqi Zhang, Lingdong Kong, Qiqi Li, Zhe Liu, Min Lie, Junliang Li, Yao Wang*, Anlong Xu*. Suppressing FXR promotes antiviral effects of bile acids via enhancing the interferon transcription. Acta Pharmaceutica Sinica B, (2024) Aug;14(8):3513-3527. 中科院一区 IF：14.7

5. Jinyong Wang^#, Fang Xie^#, Xin Jia^#, Xuejiao Wang，Lingdong Kong，Yiying Li，Xue Liang，Meiqi Zhang，Yuting He，Wandi Feng，Tong Luo，Yao Wang*，Anlong Xu*. Fangchinoline Induces Antiviral Response by Suppressing STING Degradation. Journal of Pharmaceutical Analysis, (2024) Jun;14(6):100972. 中科院一区 IF：8.8

6. Xin Jia, Meiqi Zhang, Haojia Wang, Cuiqin Cheng, Qiqi Li, Lingdong Kong, Yiying Li, Xihong Lan, Shaochun Yuan, Yao Wang*, Anlong Xu*. ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function. Journal of Medical Virology. 95(3):e28637. (2023) IF：20.693

7. Tong Luo^#, Xin Jia^#, Wandi Feng^#, Jinyong Wang, Fang Xie, Lingdong Kong, Xuejiao Wang, Rui Lian, Xia Liu, Yingjie Chu, Yao Wang*, Anlong Xu*. Bergapten suppresses NLRP3 inflammasome activation and pyroptosis via promoting mitophagy. Acta Pharmacologica Sinica. Sep;44(9):1867-1878. (2023) 中科院一区 IF：8.2

8. Meiqi Zhang^#, Xin Jia^#, Cuiqin Cheng, Haojia Wang, Lingdong Kong, Yiying Li, Qiqi Li, Fang Xie, Zhanhong Jia, Wandi Feng, Tong Luo, Yao Wang*, Anlong Xu*. Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection. Acta Pharmacologica Sinica. Nov;44 (11):2253-2264. (2023)中科院一区 IF：8.2

9. Haojia Wang^#, Xin Jia^#, Meiqi Zhang^#, Cuiqin Cheng, Xue Liang, Xuejiao Wang, Fang Xie, Jinyong Wang, Yanli Yu, Yuting He, Qiutong Dong, Yao Wang*, Anlong Xu*. Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling. Jun:114:154786. (2023) Phytomedicine. 中科院一区 IF：7.9

10. Xin Jia^#, Shaochun Yuan^#, Yao Wang^#, Yonggui Fu, Yong Ge, Yutong Ge, Xihong Lan, Yuchao Feng, Feifei Qiu, Peiyi Li, Shangwu Chen, Anlong Xu*. The role of alternative polyadenylation in the antiviral innate immune response. Nature Communications. 8:14605. (2017) 中科院一区 IF：17.7

联系方式：

yaowang@bucm.edu.cn